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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2010 2
2011 1
2012 5
2013 3
2014 3
2016 5
2017 5
2018 3
2019 7
2020 10
2021 4
2022 9
2023 7
2024 4

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59 results

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Page 1
RACGAP1 promotes proliferation and cell cycle progression by regulating CDC25C in cervical cancer cells.
Ruan X, Jiang J. Ruan X, et al. Tissue Cell. 2022 Jun;76:101804. doi: 10.1016/j.tice.2022.101804. Epub 2022 Apr 25. Tissue Cell. 2022. PMID: 35489195
RACGAP1 associated genes, including CDC25C, were mainly enriched in cell cycle pathway, and RACGAP1 expression was negatively associated with CDC25C expression. ...In mechanism, overexpression of CDC25C attenuated RACGAP1 knockdown-mediated c …
RACGAP1 associated genes, including CDC25C, were mainly enriched in cell cycle pathway, and RACGAP1 expression w …
Screening and identification of key biomarkers in hepatocellular carcinoma: Evidence from bioinformatic analysis.
Li L, Lei Q, Zhang S, Kong L, Qin B. Li L, et al. Oncol Rep. 2017 Nov;38(5):2607-2618. doi: 10.3892/or.2017.5946. Epub 2017 Sep 7. Oncol Rep. 2017. PMID: 28901457 Free PMC article.
The enriched functions and pathways of the DEGs include protein activation cascade, complement activation, carbohydrate binding, complement and coagulation cascades, mitotic cell cycle and oocyte meiosis. Sixteen hub genes were identified and biological process anal …
The enriched functions and pathways of the DEGs include protein activation cascade, complement activation, carbohydrate binding, complement …
RACGAP1 promotes the progression and poor prognosis of lung adenocarcinoma through its effects on the cell cycle and tumor stemness.
Liu Y, Han T, Miao R, Zhou J, Guo J, Xu Z, Xing Y, Bai Y, Wu J, Hu D. Liu Y, et al. BMC Cancer. 2024 Jan 2;24(1):7. doi: 10.1186/s12885-023-11761-x. BMC Cancer. 2024. PMID: 38167018 Free PMC article.
Lastly, functional analysis of the key genes was conducted through cell scratch assays, colony formation assays, transwell migration assays, flow cytometry cell cycle analysis, and xenograft tumor models. ...Knockdown of RACGAP1 suppressed the migratio …
Lastly, functional analysis of the key genes was conducted through cell scratch assays, colony formation assays, transwell migration …
RACGAP1 is transcriptionally regulated by E2F3, and its depletion leads to mitotic catastrophe in esophageal squamous cell carcinoma.
Zhao W, Wang M, Wang C, Liu Y, Liu H, Luo S. Zhao W, et al. Ann Transl Med. 2020 Aug;8(15):950. doi: 10.21037/atm-20-2901. Ann Transl Med. 2020. PMID: 32953750 Free PMC article.
Cell cycle analysis and immunofluorescence assays were used to investigate the function of RACGAP1 involvement in mitotic catastrophe. ...RACGAP1, a novel cell cycle associated gene regulated by E2F3, acts as an oncogenic driver in ESCC …
Cell cycle analysis and immunofluorescence assays were used to investigate the function of RACGAP1 involvement in mitot …
Oncogenic and immunological roles of RACGAP1 in pan-cancer and its potential value in nasopharyngeal carcinoma.
Zheng CS, Huang WM, Xia HM, Mi JL, Li YQ, Liang HQ, Zhou L, Lu ZX, Wu F. Zheng CS, et al. Apoptosis. 2024 Feb;29(1-2):243-266. doi: 10.1007/s10495-023-01884-8. Epub 2023 Sep 5. Apoptosis. 2024. PMID: 37670104
The results discovered that RACGAP1 expression was elevated in most cancers and suggested poor prognosis, which could be related to the involvement of RACGAP1 in various cancer-related pathways such as the cell cycle and correlated with RACGAP1 …
The results discovered that RACGAP1 expression was elevated in most cancers and suggested poor prognosis, which could be related to t …
Progressive loss of RacGAP1/ogre activity has sequential effects on cytokinesis and zebrafish development.
Warga RM, Wicklund A, Webster SE, Kane DA. Warga RM, et al. Dev Biol. 2016 Oct 15;418(2):307-22. doi: 10.1016/j.ydbio.2016.06.021. Epub 2016 Jun 23. Dev Biol. 2016. PMID: 27339293 Free article.
We report here that the early arrest mutant ogre is a maternal and zygotic loss of function mutation in the zebrafish homolog of racgap1. Like the other model organisms in which racgap1 is mutated, cells in the mutant stop dividing. In vivo cell recordings re …
We report here that the early arrest mutant ogre is a maternal and zygotic loss of function mutation in the zebrafish homolog of racgap1 …
Cytokinesis machinery promotes cell dissociation from collectively migrating strands in confinement.
Law RA, Kiepas A, Desta HE, Perez Ipiña E, Parlani M, Lee SJ, Yankaskas CL, Zhao R, Mistriotis P, Wang N, Gu Z, Kalab P, Friedl P, Camley BA, Konstantopoulos K. Law RA, et al. Sci Adv. 2023 Jan 13;9(2):eabq6480. doi: 10.1126/sciadv.abq6480. Epub 2023 Jan 11. Sci Adv. 2023. PMID: 36630496 Free PMC article.
We hypothesized that the spatially confining architecture of peritumor stroma promotes metastatic cell dissemination by remodeling cell-cell adhesive interactions. ...Cell dissociation is triggered by myosin IIA (MIIA) dismantling of E-cadherin cell …
We hypothesized that the spatially confining architecture of peritumor stroma promotes metastatic cell dissemination by remodeling …
Neuroblastoma cells depend on HDAC11 for mitotic cell cycle progression and survival.
Thole TM, Lodrini M, Fabian J, Wuenschel J, Pfeil S, Hielscher T, Kopp-Schneider A, Heinicke U, Fulda S, Witt O, Eggert A, Fischer M, Deubzer HE. Thole TM, et al. Cell Death Dis. 2017 Mar 2;8(3):e2635. doi: 10.1038/cddis.2017.49. Cell Death Dis. 2017. PMID: 28252645 Free PMC article.
Genes necessary for mitotic cell cycle progression and cell division were most prominently enriched in at least two of three time points in whole-genome expression data combined from two cell systems, and all nine genes in these functional categories w …
Genes necessary for mitotic cell cycle progression and cell division were most prominently enriched in at least two of …
Analysis of 20 genes at chromosome band 12q13: RACGAP1 and MCRS1 overexpression in nonsmall-cell lung cancer.
Liang Y, Liu M, Wang P, Ding X, Cao Y. Liang Y, et al. Genes Chromosomes Cancer. 2013 Mar;52(3):305-15. doi: 10.1002/gcc.22030. Epub 2012 Dec 8. Genes Chromosomes Cancer. 2013. PMID: 23225332
Furthermore, RACGAP1 downregulation by RNA interference caused cytokinesis defects, indicating that RACGAP1 is required for cytokinesis. ...In vitro, downregulation of MCRS1 in lung cancer cells inhibited cell proliferation, increased apoptosis, and induced …
Furthermore, RACGAP1 downregulation by RNA interference caused cytokinesis defects, indicating that RACGAP1 is required for cy …
Transcription profiling of feline mammary carcinomas and derived cell lines reveals biomarkers and drug targets associated with metabolic and cell cycle pathways.
Granados-Soler JL, Taher L, Beck J, Bornemann-Kolatzki K, Brenig B, Nerschbach V, Ferreira F, Junginger J, Hewicker-Trautwein M, Murua Escobar H, Nolte I. Granados-Soler JL, et al. Sci Rep. 2022 Oct 11;12(1):17025. doi: 10.1038/s41598-022-20874-5. Sci Rep. 2022. PMID: 36220861 Free PMC article.
DEGs in tumours were predominantly upregulated; dysregulation of CLs transcriptome was more extensive, including mostly downregulated genes. Cell-cycle and metabolic-related DEGs were upregulated in both tumours and CLs, including therapeutically-targetable cell …
DEGs in tumours were predominantly upregulated; dysregulation of CLs transcriptome was more extensive, including mostly downregulated genes. …
59 results